Article
Manganese superoxide dismutase polymorphism and risk of gastric lesions, and its effects on chemoprevention in a Chinese population.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Apr 2010
Tu Hua-kang, Pan Kai-feng, Zhang Yang, Li Wen-qing, Zhang Lian, Ma Jun-ling, Li Ji-you, You Wei-cheng
Abstract excerpt
BACKGROUND: Manganese superoxide dismutase is the primary antioxidant enzyme in the mitochondria and is involved in carcinogenesis. To investigate the association between MnSOD Val(16)Ala polymorphism and risk of advanced gastric lesions, and its effects on chemoprevention, a population-based study was conducted in Linqu, a high-risk area of gastric cancer in China. METHODS: Genotypes were determined by PCR-RFLP...
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