Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dietary fish oil promotes colonic apoptosis and mitochondrial proton leak in oxidatively stressed mice.

Cancer prevention research (Philadelphia, Pa.) - 1 Aug 2011

Fan Yang-Yi, Ran Qitao, Toyokuni Shinya, Okazaki Yasumasa, Callaway Evelyn S, Lupton Joanne R, Chapkin Robert S

Abstract excerpt

An alteration of mitochondrial function can result in disruption of redox homeostasis and is associated with abnormal cancer cell growth. Manganese superoxide dismutase (SOD2) and glutathione peroxidase 4 (Gpx4) are two of the most important antioxidant defense enzymes that protect cells against...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiolipins
Share to Colon
Share to Crosses, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fish Oils

Share to Glutathione Peroxidase

Share to Oxidative Stress

Share to Oxygen Consumption

Share to Protons

Source

Open in PubMed Open full text

Identifiers

PMID: 21490130
DOI: 10.1158/1940-6207.CAPR-10-0368
PMCID: PMC3137683

Genes

SOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21490130-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dietary fish oil promotes colonic apoptosis and mitochondrial proton leak in oxidatively stressed mice.PMID 21490130Read ↗

Long-lived alphaMUPA transgenic mice show reduced SOD2 expression, enhanced apoptosis and reduced susceptibility to the carcinogen dimethylhydrazine.Semantic proximity Read ↗

Glutathione peroxidase 4 suppresses manganese-dependent oxidative stress to reduce colorectal tumorigenesis.Semantic proximity Read ↗

A bioassay to measure energy metabolism in mouse colonic crypts, organoids, and sorted stem cells.Semantic proximity Read ↗

Carnitine deficiency in OCTN2-/- newborn mice leads to a severe gut and immune phenotype with widespread atrophy, apoptosis and a pro-inflammatory response.Semantic proximity Read ↗

The loss of antioxidant activities impairs intestinal epithelium homeostasis by altering lipid metabolismSemantic proximity Read ↗

Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain.Semantic proximity Read ↗

Spontaneous development of intestinal and colonic atrophy and inflammation in the carnitine-deficient jvs (OCTN2(-/-)) mice.Semantic proximity Read ↗

Effect of cyclooxygenase genotype and dietary fish oil on colonic eicosanoids in mice.Semantic proximity Read ↗

Mitochondrial gene polymorphisms that protect mice from colitis.Semantic proximity Read ↗

Amelioration of diabesity-induced colorectal ontogenesis by omega-3 fatty acids in mice.Semantic proximity Read ↗

Conjugated EPA activates mutant p53 via lipid peroxidation and induces p53-dependent apoptosis in DLD-1 colorectal adenocarcinoma human cells.Semantic proximity Read ↗

Manganese Superoxide Dismutase Induces p53-Dependent Senescence in Colorectal Cancer CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.