Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mice with combined disruption of Gpx1 and Gpx2 genes have colitis.

American journal of physiology. Gastrointestinal and liver physiology - 1 Sept 2001

Esworthy R S, Aranda R, Martín M G, Doroshow J H, Binder S W, Chu F F

Abstract excerpt

Glutathione peroxidase (GPX)-1 and gastrointestinal (GI) epithelium-specific GPX (GPX-GI), encoded by Gpx1 and Gpx2, provide most GPX activity in GI epithelium. Although homozygous mice deficient in either the Gpx1 or Gpx2 gene appeared to be normal under standard housing conditions, homozygous m...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colitis
Share to Colon
Share to Glutathione Peroxidase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutathione Peroxidase GPX1

Share to Growth Disorders

Share to Peroxidase

Share to Rectum

Source

Identifiers

PMID: 11518697
DOI: 10.1152/ajpgi.2001.281.3.G848

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11518697-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mice with combined disruption of Gpx1 and Gpx2 genes have colitis.PMID 11518697Read ↗

The Gdac1 locus modifies spontaneous and Salmonella-induced colitis in mice deficient in either Gpx2 or Gpx1 gene.Semantic proximity Read ↗

Mutation accumulation in the intestine and colon of mice deficient in two intracellular glutathione peroxidases.Semantic proximity Read ↗

Colitis locus on chromosome 2 impacting the severity of early-onset disease in mice deficient in GPX1 and GPX2.Semantic proximity Read ↗

Analysis of candidate colitis genes in the Gdac1 locus of mice deficient in glutathione peroxidase-1 and -2.Semantic proximity Read ↗

Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain.Semantic proximity Read ↗

Glutathione peroxidase 4 suppresses manganese-dependent oxidative stress to reduce colorectal tumorigenesis.Semantic proximity Read ↗

Increased susceptibility of chronic ulcerative colitis-induced carcinoma development in DNA repair enzyme Ogg1 deficient mice.Semantic proximity Read ↗

Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis.Semantic proximity Read ↗

Different effects of the Cdx1 and Cdx2 homeobox genes in a murine model of intestinal inflammation.Semantic proximity Read ↗

Epithelial dysfunction associated with the development of colitis in conventionally housed mdr1a-/- mice.Semantic proximity Read ↗

Cdx1 induced intestinal metaplasia in the transgenic mouse stomach: comparative study with Cdx2 transgenic miceSemantic proximity Read ↗

Deficiency of Protein Tyrosine Phosphatase Non-Receptor Type 2 in Intestinal Epithelial Cells Has No Appreciable Impact on Dextran Sulphate Sodium Colitis Severity But Promotes Wound Healing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.