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Article

A transient CD87-centred axis enhances the Th17 potential of cDC2 in neonates

2026-06-12

Abstract excerpt

Type 2 conventional dendritic cells (cDC2) orchestrate T cell immunity, yet the signals that regulate their tissue-specific functions across development remain poorly defined. We demonstrate that splenic cDC2/DC3 subset heterogeneity is established perinatally and that splenic ESAM hi cDC2A undergo a transcriptional and functional transition around the time of weaning, which occurs independently of microbiota. Co...

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Identifiers and source

Literature Corpus work
c5695b61-1bdb-5ef0-8bc5-214dd5a2ba4e
DOI
10.64898/2026.06.12.731823
Open publication

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A transient CD87-centred axis enhances the Th17 potential of cDC2 in neonatesDOI 10.64898/2026.06.12.731823
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