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Single-cell transcriptomic analysis reveals heterogeneous features of myeloid-derived suppressor cells in newborns

11 Jun 2024

Abstract excerpt

The transitory emergence of myeloid-derived suppressor cells (MDSCs) in infants is important for the homeostasis of the immune system in early life. The composition and functional heterogeneity of MDSCs in newborns remain elusive, hampering the understanding of the importance of MDSCs in neonates. In this study, we unraveled the maturation trajectory of polymorphonuclear (PMN)-MDSCs from the peripheral blood of...

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PMID: 38919617
DOI: 10.3389/fimmu.2024.1367230

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