Article

A deep reinforcement learning platform for antibiotic discovery

2025-09-23

Abstract excerpt

Antimicrobial resistance (AMR) is projected to cause up to 10 million deaths annually by 2050, underscoring the urgent need for new antibiotics. Here we present ApexAmphion, a deep-learning framework for de novo design of antibiotics that couples a 6.4-billion-parameter protein language model with reinforcement learning. The model is first fine-tuned on curated peptide data to capture antimicrobial sequence regul...

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Literature Corpus work: a45d03b7-69b6-527b-beac-24d2bbf2c297
DOI: 10.1101/2025.09.23.678086

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