Article

Targeting breast cancer senescence in 3D models of bone metastasis

2025-06-30

Abstract excerpt

Chemotherapeutic treatment of breast cancer with Doxorubicin can induce tumor and stromal cell senescence leading to therapy-resistance. Senescence-associated secretory phenotype (SASP) promotes secretion of pro-inflammatory and tumorigenic factors causing systemic inflammation. Combined, this can result in immune suppression, tumor growth and secondary spread of cancer. Targeting and removing senescent and cancer...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c4f3f089-fdd5-50e3-90e4-ed4fab6d55e6
DOI: 10.1101/2025.06.26.661856

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeting breast cancer senescence in 3D models of bone metastasisDOI 10.1101/2025.06.26.661856Read

Therapy-induced senescence in breast cancer: an overviewSemantic proximity Read

Single-cell Transcriptome Analysis Identifies Senescent Osteocytes as Contributors to Bone Destruction in Breast Cancer MetastasisSemantic proximity Read

The Premature Senescence in Breast Cancer Treatment StrategySemantic proximity Read

Tumour-derived extracellular vesicles within the therapy-induced senescent secretome distinctly suppress breast cancer via DKK1-mediated inflammatory responseSemantic proximity Read

Effect of Ursolic Acid, Selenium Nanoparticles, and Their Combination on the Metastasis-Associated Gene Expression in MDA-MB-231 Breast Cancer Cells: In-vitro StudySemantic proximity Read

Robinetin Modulates TGF-β/ERK Signaling and Tumor-Associated Phenotype in 3D Osteosarcoma Spheroids.Semantic proximity Read

Potentiating doxorubicin activity through BCL-2 inhibition in p53 wild-type and mutated triple-negative breast cancerSemantic proximity Read

Role of the beta catenin destruction complex in mediating chemotherapy-induced senescence-associated secretory phenotype.Semantic proximity Read

Cellular senescence as a prognostic marker for predicting breast cancer progression in 2D and 3D organoid modelsSemantic proximity Read

Interleukin-32θ Triggers Cellular Senescence and Reduces Sensitivity to Doxorubicin-Mediated Cytotoxicity in MDA-MB-231 Cells.Semantic proximity Read

Regulation of senescence escape by TSP1 and CD47 following chemotherapy treatmentSemantic proximity Read

Carotenoid-Enriched Nanoemulsions and γ-Rays Synergistically Induce Cell Death in a Novel Radioresistant Osteosarcoma Cell LineSemantic proximity Read