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Cellular senescence as a prognostic marker for predicting breast cancer progression in 2D and 3D organoid models

4 Jul 2025

Abstract excerpt

Breast cancer is the most prevalent malignancy in women, with its heterogeneity complicating prognosis and treatment development. This study explores the role of cellular senescence in breast cancer progression using three breast cancer cell lines-two triple-negative (HS578T, MDA-MB-231) and one luminal A (T47D)-alongside a non-tumorigenic breast epithelial cell line (MCF10a) as control. Findings were validated...

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PMID: 40616881
DOI: 10.1016/j.biopha.2025.118324

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