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Article

Robinetin Modulates TGF-β/ERK Signaling and Tumor-Associated Phenotype in 3D Osteosarcoma Spheroids.

ACS biomaterials science & engineering - 10 Aug 2026

Santos Isabela, Han Seokgyu, Hernández Zapata Omar Gabriel, Corral Brittany Alejandra Garibay, Lee Jihyun, Conceição Francisco, Oliveira José Miguel P Ferreira de, Fernandes Eduarda, Shin Su Ryon

Abstract excerpt

Osteosarcoma (OS) is the most frequent primary bone malignancy, with stagnant therapeutic progress. The current chemotherapy treatment shows limited efficacy in disseminating metastasis, and its recurrent use is associated with high systemic toxicity. Moreover, the absence of effective therapeutic strategies along with low complexity models for drug screen analysis hinders therapeutic progress. Herein, by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42479611
DOI: 10.1021/acsbiomaterials.6c00437

Genes

IL6
MMP2
FN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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