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Article

Role of the beta catenin destruction complex in mediating chemotherapy-induced senescence-associated secretory phenotype.

PloS one - 1 Jan 2012

Basu Dipanjan, Reyes-Mugica Miguel, Rebbaa Abdelhadi

Abstract excerpt

Cellular senescence is considered as a tumor suppressive mechanism. Recent evidence indicates however that senescent cells secrete various growth factors and cytokines, some of which may paradoxically promote cancer progression. This phenomenon termed senescence-associated secretory phenotype (SASP) must be inhibited in order for anti-proliferative agents to be effective. The present study was designed to...

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Identifiers

PMID: 23272224
DOI: 10.1371/journal.pone.0052188
PMCID: PMC3525570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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