Article

Case-Base-Control designs

2019-08-02

Abstract excerpt

Most genome-wide association studies (GWASs) use randomly selected samples from the population (hereafter bases) as the control set. This approach is successful when the trait of interest is rare; otherwise, a loss in the statistical power to detect disease-associated variants is expected. To address this, a proposal to combine the three sample types, cases, controls and bases is introduced, for instances when the...

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Literature Corpus work: c4aad823-6d65-5c4a-b5f6-53d922959dea
DOI: 10.1101/723452

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