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Article

A general framework for studying genetic effects and gene-environment interactions with missing data.

Biostatistics (Oxford, England) - 1 Oct 2010

Hu Y J, Lin D Y, Zeng D

Abstract excerpt

Missing data arise in genetic association studies when genotypes are unknown or when haplotypes are of direct interest. We provide a general likelihood-based framework for making inference on genetic effects and gene-environment interactions with such missing data. We allow genetic and environmental variables to be correlated while leaving the distribution of environmental variables completely unspecified. We...

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Identifiers

PMID: 20348396
DOI: 10.1093/biostatistics/kxq015
PMCID: PMC3294269

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