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Article

Sampling strategies for rare variant tests in case-control studies.

European journal of human genetics : EJHG - 1 Oct 2012

Zöllner Sebastian

Abstract excerpt

Advances in sequencing technology allow assessing the impact of rare variation on common disorders. For this purpose, methods combine rare variants across a gene and compare an aggregate statistic between cases and controls. However, sequencing many individuals is costly. Hence, it is necessary to identify case samples that are most likely to result in powerful tests under realistic model assumptions. Power can...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22510851
DOI: 10.1038/ejhg.2012.58
PMCID: PMC3449077

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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