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Article

Comparison of common burden tests for genetic association studies of rare variants.

Yi chuan = Hereditas - 20 Feb 2018

Lin Xin-Qi, Liang Rong, Zhang Jun-Guo, Pi Lu-Cheng, Chen Si-Dong, Liu Li, Gao Yan-Hui

Abstract excerpt

Common burden tests have different statistical performance in genetic association studies of rare variants. Here, we compare the statistical performance of burden tests, such as CMC, WST, SUM and extension methods, using the computer-simulated datasets of rare variants with different parameters of sample sizes, linkage disequilibrium (LD), and different numbers of mixed non-associated variants. The simulation...

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PMID: 29428909
DOI: 10.16288/j.yczz.17-174

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