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Article

Statistical tests of genetic association for case-control study designs.

Biostatistics (Oxford, England) - 1 Sept 2012

Wang Kai

Abstract excerpt

The central theme in case-control genetic association studies is to efficiently identify genetic markers associated with trait status. Powerful statistical methods are critical to accomplishing this goal. A popular method is the omnibus Pearson's chi-square test applied to genotype counts. To achieve increased power, tests based on an assumed trait model have been proposed. However, they are not robust to model...

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Share to Case-Control Studies
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Genome-Wide Association Study

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait, Heritable

Source

Identifiers

PMID: 22389176
DOI: 10.1093/biostatistics/kxs002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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