Article
Variation in sequence and organization of splicing regulatory elements in vertebrate genes.
Proceedings of the National Academy of Sciences of the United States of America - 2 Nov 2004
Yeo Gene, Hoon Shawn, Venkatesh Byrappa, Burge Christopher B
Abstract excerpt
Although core mechanisms and machinery of premRNA splicing are conserved from yeast to human, the details of intron recognition often differ, even between closely related organisms. For example, genes from the pufferfish Fugu rubripes generally contain one or more introns that are not properly spliced in mouse cells. Exploiting available genome sequence data, a battery of sequence analysis techniques was used to...
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