Article

XAF1 Inactivation Increases Tumor Cell Resistance to Endoplasmic Reticulum Stress-Induced Apoptosis Through Stabilization of GRP78 and CHIP

2022-03-17

Abstract excerpt

Despite accumulating evidence for the pro-apoptotic role for X-linked inhibitor of apoptosis-associated factor 1 (XAF1), its involvement in endoplasmic reticulum (ER) stress response remains undefined. Here, we report that XAF1 enhances cell sensitivity to ER stress and acts as a switch in unfolded protein response (UPR)-mediated cell-fate decisions favoring apoptosis over adaptive autophagy. XAF1 interacts with a...

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Literature Corpus work: c46e07e9-4eae-52f8-aa79-23d2c3c19458
DOI: 10.20944/preprints202203.0251.v1

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