Article
Identification of a novel splice variant of X-linked inhibitor of apoptosis-associated factor 1.
Biochemical and biophysical research communications - 27 Jan 2006
Yin Weihong, Cheepala Satish, Clifford John L
Abstract excerpt
XAF1 (XIAP-associated factor 1) binds to XIAP and blocks its anti-apoptotic activity. It has been reported that XAF1 is mainly expressed in normal tissues but is missing or present at low levels in most cancer cell lines, which implies a tumor-suppressing function. In the present study we describe the identification of a novel splice variant of human XAF1, designated XAF1C, which contains a cryptic exon....
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