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The emerging role of XBP1 in cancer

12 Apr 2020

Abstract excerpt

X-box binding protein 1 (XBP1) is a unique basic-region leucine zipper (bZIP) transcription factor whose dynamic form is controlled by an alternative splicing response upon disturbance of homeostasis in the endoplasmic reticulum (ER) and activation of the unfolded protein response (UPR). XBP1 was first distinguished as a key regulator of major histocompatibility complex (MHC) class II gene expression in B cells....

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PMID: 32294597
DOI: 10.1016/j.biopha.2020.110069

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