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Article

A novel XBP1 variant is highly enriched in cancer tissues and is specifically required for cancer cell survival.

Biochemical and biophysical research communications - 12 Jul 2021

Zhong Yongwang, Yan Wenjing, Ruan Jingjing, Fang Mike, Lapidus Rena G, Du Shaojun, Fang Shengyun

Abstract excerpt

XBP1 is a basic leucine zipper (bZIP) transcription factor and a key mediator of the endoplasmic reticulum (ER) stress-activated unfolded protein response (UPR). XBP1-mediated transcription facilitates cell adaptation to ER stress and also promotes tumor progression, while suppressing anti-tumor immunity. Here we report a novel XBP1 variant, namely XBP1 variant 1 (XBP1v1, Xv1 for short), that is specifically...

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Source

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Identifiers

PMID: 34038755
DOI: 10.1016/j.bbrc.2021.05.038
PMCID: PMC8206033

Genes

XBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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