Article

Bayesian estimation of cell-type-specific gene expression per bulk sample with prior derived from single-cell data

2020-08-06

Abstract excerpt

When assessed over a large number of samples, bulk RNA sequencing provides reliable data for gene expression at the tissue level. Single-cell RNA sequencing (scRNA-seq) deepens those analyses by evaluating gene expression at the cellular level. Both data types lend insights into disease etiology. With current technologies, however, scRNA-seq data are known to be noisy. Moreover, constrained by costs, scRNA-seq dat...

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Literature Corpus work: 94b0b41c-fb79-5fca-99fe-cf5325a84ba9
DOI: 10.1101/2020.08.05.238949

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