Article

p120 RasGAP and ZO-2 are essential for Hippo signaling and tumor suppressor function mediated by p190A RhoGAP

2023-05-23

Abstract excerpt

<h4>Summary</h4> ARHGAP35 , which encodes p190A RhoGAP (p190A), is a major cancer gene. p190A is a tumor suppressor that activates the Hippo pathway. p190A was originally cloned via direct binding to p120 RasGAP (RasGAP). Here, we determine that a novel interaction of p190A with the tight junction-associated protein ZO-2 is dependent on RasGAP. We establish that both RasGAP and ZO-2 are necessary for p190A to act...

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Literature Corpus work: c430c1da-25c2-57a4-b6be-2cb33a08c464
DOI: 10.1101/2023.05.22.541483

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