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Article

p190 RhoGAP, the major RasGAP-associated protein, binds GTP directly.

Molecular and cellular biology - 1 Nov 1994

Foster R, Hu K Q, Shaywitz D A, Settleman J

Abstract excerpt

In mitogenically stimulated cells, a specific complex forms between the Ras GTPase-activating protein (RasGAP) and the cellular protein p190. We have previously reported that p190 contains a carboxy-terminal domain that functions as a GAP for the Rho family GTPases. Thus, the RasGAP-p190 complex may serve to couple Ras- and Rho-mediated signalling pathways. In addition to its RhoGAP domain, p190 contains an...

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Identifiers

PMID: 7935432
DOI: 10.1128/mcb.14.11.7173-7181.1994
PMCID: PMC359251

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p190 RhoGAP, the major RasGAP-associated protein, binds GTP directly.PMID 7935432Read ↗

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