Article
p190 RhoGAP, the major RasGAP-associated protein, binds GTP directly.
Molecular and cellular biology - 1 Nov 1994
Foster R, Hu K Q, Shaywitz D A, Settleman J
Abstract excerpt
In mitogenically stimulated cells, a specific complex forms between the Ras GTPase-activating protein (RasGAP) and the cellular protein p190. We have previously reported that p190 contains a carboxy-terminal domain that functions as a GAP for the Rho family GTPases. Thus, the RasGAP-p190 complex...
Topics
- Amino Acid Sequence
- Animals
- Baculoviridae
- Binding Sites
- Consensus Sequence
- GTP-Binding Proteins
- GTPase-Activating Proteins
- Guanosine Triphosphate
- Hydrolysis
- Kinetics
- Molecular Sequence Data
- Molecular Weight
- Mutation
- Nucleoside-Diphosphate Kinase
- Protein Binding
- Proteins
- Rats
- Sequence Homology, Amino Acid