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Article

Cancer-associated mutations in the protrusion-targeting region of p190RhoGAP impact tumor cell migration.

The Journal of cell biology - 26 Sept 2016

Binamé Fabien, Bidaud-Meynard Aurélien, Magnan Laure, Piquet Léo, Montibus Bertille, Chabadel Anne, Saltel Frédéric, Lagrée Valérie, Moreau Violaine

Abstract excerpt

Spatiotemporal regulation of RhoGTPases such as RhoA is required at the cell leading edge to achieve cell migration. p190RhoGAP (p190A) is the main negative regulator of RhoA and localizes to membrane protrusions, where its GTPase-activating protein (GAP) activity is required for directional migration. In this study, we investigated the molecular processes responsible for p190A targeting to actin protrusions. By...

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Identifiers

PMID: 27646271
DOI: 10.1083/jcb.201601063
PMCID: PMC5037408

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