Article
A Point Mutation in p190A RhoGAP Affects Ciliogenesis and Leads to Glomerulocystic Kidney Defects.
PLoS genetics - 1 Feb 2016
Stewart Katherine, Gaitan Yaned, Shafer Maxwell E R, Aoudjit Lamine, Hu Di, Sharma Richa, Tremblay Mathieu, Ishii Hidetaka, Marcotte Michael, Stanga Daniela, Tang You Chi, Boualia Sami Kamel, Nguyen Alana H T, Takano Tomoko, Lamarche-Vane Nathalie, Vidal Silvia, Bouchard Maxime
Abstract excerpt
Rho family GTPases act as molecular switches regulating actin cytoskeleton dynamics. Attenuation of their signaling capacity is provided by GTPase-activating proteins (GAPs), including p190A, that promote the intrinsic GTPase activity of Rho proteins. In the current study we have performed a small-scale ENU mutagenesis screen and identified a novel loss of function allele of the p190A gene Arhgap35, which...
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