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Article

Islet-specific T-cell responses and proinflammatory monocytes define subtypes of autoantibody-negative ketosis-prone diabetes.

Diabetes care - 1 Dec 2013

Brooks-Worrell Barbara M, Iyer Dinakar, Coraza Ivonne, Hampe Christiane S, Nalini Ramaswami, Ozer Kerem, Narla Radhika, Palmer Jerry P, Balasubramanyam Ashok

Abstract excerpt

OBJECTIVE: Ketosis-prone diabetes (KPD) is characterized by diabetic ketoacidosis (DKA) in patients lacking typical features of type 1 diabetes. A validated classification scheme for KPD includes two autoantibody-negative ("A-") phenotypic forms: "A-β-" (lean, early onset, lacking β-cell functional reserve) and "A-β+" (obese, late onset, with substantial β-cell functional reserve after the index episode of DKA)....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24130366
DOI: 10.2337/dc12-2328
PMCID: PMC3836121

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