Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

β-Cell Dedifferentiation in HOMA-βlow and HOMA-βhigh Subjects

10 Aug 2024

Abstract excerpt

CONTEXT: β-Cell dedifferentiation ratio is increased in type 2 diabetes; but its direct link to in vivo β-cell function in human remains unclear. OBJECTIVE: The present study was designed to investigate whether β-cell dedifferentiation in situ was closely associated with β-cell function in vivo and to identify targets crucial for β-cell dedifferentiation/function in human. METHODS: We acquired homeostasis model...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Pancreatic and Hepatic Oncology Research
Share to Pancreatic function and diabetes
Share to Pancreatitis Pathology and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39133811
DOI: 10.1210/clinem/dgae538

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

β-Cell Dedifferentiation in HOMA-βlow and HOMA-βhigh SubjectsPMID 39133811Read ↗

Alterations in Beta Cell Identity in Type 1 and Type 2 DiabetesSemantic proximity Read ↗

Evidence for Loss in Identity, De-Differentiation, and Trans-Differentiation of Islet β-Cells in Type 2 DiabetesSemantic proximity Read ↗

Plasticity and Dedifferentiation within the Pancreas: Development, Homeostasis, and DiseaseSemantic proximity Read ↗

RNA-Seq Analysis of Islets to Characterise the Dedifferentiation in Type 2 Diabetes Model Mice db/dbSemantic proximity Read ↗

Beta cell dedifferentiation in type 1 diabetes: sacrificing function for survival?Semantic proximity Read ↗

Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice.Semantic proximity Read ↗

PDX1 is the cornerstone of pancreatic β-cell functions and identitySemantic proximity Read ↗

Single-cell transcriptomics of human islet ontogeny defines the molecular basis of β-cell dedifferentiation in T2DSemantic proximity Read ↗

Multi-omics analysis of long-term cultured human isletsSemantic proximity Read ↗

AFF3 and BACH2 are master regulators of metabolic inflexibility, β/α-cell transition, and dedifferentiation in type 2 diabetesSemantic proximity Read ↗

The Plasticity of Pancreatic β-CellsSemantic proximity Read ↗

Targeting β-cell dedifferentiation and transdifferentiation: opportunities and challengesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.