Plasma Lipidomics Reveals Reproducible Coordinated Lipid Programs Associated with Organ Failure in Acute-on-Chronic Liver Failure

Abstract excerpt

<title>Abstract</title> <p>Background Acute-on-chronic liver failure (ACLF) is characterized by severe systemic inflammation, progressive organ failure, and high short-term mortality. Although numerous alterations in circulating lipids have been described in ACLF and other forms of critical illness, it remains unclear whether biologically meaningful information resides primarily in individual lipid species or em...

Topics

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• Diet, High-Fat
• Lipid Metabolism
• Lipids
• Liver
• Liver Disease and Transplantation
• Liver Disease Diagnosis and Treatment
• Mice, Inbred DBA
• Non-alcoholic Fatty Liver Disease

Identifiers and source

Literature Corpus work

c3d55265-962c-5b85-be36-2285a8b0735e

DOI

10.21203/rs.3.rs-10402655/v1