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Article

Transcriptomics reveals immune-metabolism disorder in acute-on-chronic liver failure in rats

1 Dec 2021

Abstract excerpt

Acute-on-chronic liver failure (ACLF) is clinical syndrome with high mortality rate. This study aimed to perform detailed transcriptomic analysis in liver cirrhosis–based ACLF rats to elucidate ACLF pathogenesis. ACLF was induced by combined porcine serum with D-galactosamine and lipopolysaccharide. Gene expression profile of liver tissues from ACLF rats was generated by transcriptome sequencing to reveal the...

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PMID: 34853163
DOI: 10.26508/lsa.202101189

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