Article

Endosulfan rewires PKA and GSK3β to disrupt primary cilia-dependent Hedgehog signalling

2026-07-03

Abstract excerpt

Primary cilium-dependent Hedgehog signalling is essential for embryonic development, tissue patterning, and organ homeostasis, and its disruption causes a spectrum of developmental disorders collectively termed ciliopathies. Whether environmental toxicants can chemically induce ciliopathy-like states by targeting this pathway, however, remains poorly understood. Here we show that endosulfan, a banned organochlorin...

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Literature Corpus work: c3c9f76b-d6e1-5cd3-bcfc-cb61775455ba
DOI: 10.64898/2026.07.03.736336

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