Article

Conformational activation of GSK3β by an environmental toxicant suppresses hedgehog signalling and disrupts ciliary homeostasis

2026-08-07

Abstract excerpt

Primary cilium-dependent hedgehog signalling is essential for embryonic development, tissue patterning, and organ homeostasis, and its dysfunction causes ciliopathies, a clinically diverse spectrum of developmental and reproductive disorders. Whether environmental chemicals can phenocopy genetic ciliopathies by directly targeting ciliary kinase machinery has remained unknown. Here we show that endosulfan, a banned...

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Identifiers and source

Literature Corpus work: 7129cc93-57de-522c-b501-019a4865faf6
DOI: 10.64898/2026.08.03.742442

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