Article

Prenatal alcohol exposure disrupts Shh pathway and primary cilia genes in the mouse neural tube

2019-05-24

Abstract excerpt

Neurulation-stage alcohol exposure (NAE; embryonic day [E] 8-10) is associated with midline craniofacial and CNS defects that likely arise from disruption of morphogen pathways, such as Sonic hedgehog (Shh). Notably, midline anomalies are also a hallmark of genetic ciliopathies such as Joubert syndrome. We tested whether NAE alters Shh pathway signaling and the number and function of primary cilia, organelles crit...

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Literature Corpus work: 41ba8826-0d4d-5d04-bd0b-acaab51dae78
DOI: 10.1101/649673

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