Article
Definition of critical periods for Hedgehog pathway antagonist-induced holoprosencephaly, cleft lip, and cleft palate.
PloS one - 1 Jan 2015
Heyne Galen W, Melberg Cal G, Doroodchi Padydeh, Parins Kia F, Kietzman Henry W, Everson Joshua L, Ansen-Wilson Lydia J, Lipinski Robert J
Abstract excerpt
The Hedgehog (Hh) signaling pathway mediates multiple spatiotemporally-specific aspects of brain and face development. Genetic and chemical disruptions of the pathway are known to result in an array of structural malformations, including holoprosencephaly (HPE), clefts of the lip with or without cleft palate (CL/P), and clefts of the secondary palate only (CPO). Here, we examined patterns of dysmorphology caused...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.