Article

A robust and integrated framework for cross-platform adaptation of epigenetic clocks in cell-free DNA sequencing

2025-12-01

Abstract excerpt

<h4>Background.</h4> Circulating cell-free DNA (cfDNA or ccfDNA) methylation sequencing holds promise for developing epigenetic aging clocks in minimally invasive aging assessment applications. However, current clocks—primarily trained on array-based data—do not readily generalize to methylation profiles of cfDNA, due to stochasticity and uncertainty arising from the limited input amounts of cfDNA and technical c...

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Literature Corpus work: c3c7982b-17e1-5df2-9b28-95af355236d2
DOI: 10.1101/2025.11.27.690895

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