Article

Alleviating cell-free DNA sequencing biases with optimal transport

2024-04-07

Abstract excerpt

Cell-free DNA (cfDNA) is a rich source of biomarkers for various (patho)physiological conditions. Recent developments have used Machine Learning on large cfDNA data sets to enhance the detection of cancers and immunological diseases. Preanalytical variables, such as the library preparation protocol or sequencing platform, are major confounders that influence such data sets and lead to domain shifts (i.e., shifts i...

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Literature Corpus work: fbf7ecc9-75f2-56d6-a1f1-fe430df93fc1
DOI: 10.1101/2024.04.04.588204

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