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Biological versus Technical Reliability of Epigenetic Clocks and Implications for Disease Prognosis and Intervention Response

2025-10-14

Abstract excerpt

DNA methylation–based aging biomarkers, or epigenetic clocks, are increasingly used to estimate biological age and predict health outcomes. Their translational utility, however, depends not only on predictive accuracy but also on reliability, the ability to provide consistent results across technical replicates and repeated biological measures. Here, we leveraged the TranslAGE platform to comprehensively evaluate...

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Literature Corpus work
58bb3ce6-3936-580b-83e4-43ede8caf377
DOI
10.1101/2025.10.13.682176
Open publication

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