Article

Tasmanian devil facial tumor-derived extracellular vesicles reveal mesenchymal transition markers and adhesion molecules related to metastasis

2020-10-19

Abstract excerpt

Tasmanian devils are threatened with extinction by Devil Facial Tumor Disease (DFTD), which consists of two genetically independent transmissible cancers (DFT1 and DFT2). Both cancers typically cause death due to metastases. However, the mechanisms underpinning DFTD metastasis are not well understood. The nano-sized, membrane-enclosed extracellular vesicles (EVs) released by cancer cells have been implicated in me...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c3b1869e-de9c-5ddd-b1e3-60125b09f38b
DOI: 10.1101/2020.10.18.344721

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tasmanian devil facial tumor-derived extracellular vesicles reveal mesenchymal transition markers and adhesion molecules related to metastasisDOI 10.1101/2020.10.18.344721Read

Pathogenesis and Molecular Biology of a Transmissible Tumor in the Tasmanian DevilSemantic proximity Read

Gene expression of Tasmanian devil facial tumors differs among host populationsSemantic proximity Read

The Tasmanian devil transcriptome reveals Schwann cell origins of a clonally transmissible cancer.Semantic proximity Read

Extracellular Vesicle RNA Sequencing Reveals Dramatic Transcriptomic Alterations Between Metastatic and Primary Osteosarcoma in a Liquid Biopsy Approach.Semantic proximity Read

PD-L1 Is Not Constitutively Expressed on Tasmanian Devil Facial Tumor Cells but Is Strongly Upregulated in Response to IFN-γ and Can Be Expressed in the Tumor MicroenvironmentSemantic proximity Read

Comparative proteomic investigation of metastatic and non-metastatic osteosarcoma cells of human and canine originSemantic proximity Read

How the devil facial tumor disease escapes host immune responsesSemantic proximity Read

Characterization of extracellular vesicle-associated DNA and proteins derived from organotropic metastatic breast cancer cellsSemantic proximity Read

Extracellular vesicles from a novel chordoma cell line, ARF-8, promote tumorigenic microenvironmental changes when incubated with the parental cells and with human osteoblastsSemantic proximity Read

Extracellular vesicles proteins for early cancer diagnosis: From omics to biomarkersSemantic proximity Read

Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell functionSemantic proximity Read

Identification of dendritic cells, B cell and T cell subsets in Tasmanian devil lymphoid tissue; evidence for poor immune cell infiltration into devil facial tumorsSemantic proximity Read