Article
The Tasmanian devil transcriptome reveals Schwann cell origins of a clonally transmissible cancer.
Science (New York, N.Y.) - 1 Jan 2010
Murchison Elizabeth P, Tovar Cesar, Hsu Arthur, Bender Hannah S, Kheradpour Pouya, Rebbeck Clare A, Obendorf David, Conlan Carly, Bahlo Melanie, Blizzard Catherine A, Pyecroft Stephen, Kreiss Alexandre, Kellis Manolis, Stark Alexander, Harkins Timothy T, Marshall Graves Jennifer A, Woods Gregory M, Hannon Gregory J, Papenfuss Anthony T
Abstract excerpt
The Tasmanian devil, a marsupial carnivore, is endangered because of the emergence of a transmissible cancer known as devil facial tumor disease (DFTD). This fatal cancer is clonally derived and is an allograft transmitted between devils by biting. We performed a large-scale genetic analysis of D...
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