PD-L1 Is Not Constitutively Expressed on Tasmanian Devil Facial Tumor Cells but Is Strongly Upregulated in Response to IFN-γ and Can Be Expressed in the Tumor Microenvironment

Abstract excerpt

The devil facial tumor disease (DFTD) is caused by clonal transmissible cancers that have led to a catastrophic decline in the wild Tasmanian devil (Sarcophilus harrisii) population. The first transmissible tumor, now termed DFT1, was first discovered in 1996 and has been continually transmitted to new hosts for at least 20 years. In 2015 a second transmissible cancer (DFT2) was discovered in wild devils, and the...

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