Article

Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell function

2023-01-16

Abstract excerpt

Intercellular communication between different cell types in solid tumors contributes to tumor growth and metastatic dissemination. The secretome of cancer-associated fibroblasts (CAFs) plays major roles in these processes. Using human mammary CAFs, we unveil a mechanism of cell-cell communication between CAFs with myofibroblast phenotype and endothelial cells (ECs) based on intercellular protein transfer through e...

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Literature Corpus work: 234ff9f1-a9bc-5f1a-bbb6-3d4596109822
DOI: 10.1101/2023.01.13.523951

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