Article
Extracellular Vesicle RNA Sequencing Reveals Dramatic Transcriptomic Alterations Between Metastatic and Primary Osteosarcoma in a Liquid Biopsy Approach.
Annals of surgical oncology - 1 Sept 2018
Bao Qiyuan, Gong Liangzhi, Wang Jizhuang, Wen Junxiang, Shen Yuhui, Zhang Weibin
Abstract excerpt
BACKGROUND: Osteosarcoma (OS) is a highly metastasizing bone malignancy despite wide surgical resection of the primary lesion. A liquid biopsy approach to detect residual disease and identify therapeutic targets is still lacking. In this report, we aimed to track the metastasis of OS via extracellular vesicle (EV) RNA profiling in a non-invasive manner. METHODS: We applied RNA sequencing for 10 matched metastatic...
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