Article

Administration of barcoded AAV capsid library to the putamen of non-human primates identifies variants with efficient retrograde transport

2025-07-10

Abstract excerpt

<h4>ABSTRACT</h4> Adeno-associated viral vectors have become a leading choice for gene therapy in the central nervous system due to their safety profile, efficient neuronal transduction, and capacity for sustained transgene expression. We previously reported that AAV2-derived capsids developed using the BRAVE (Barcoded Rational AAV Vector Evolution) approach have enhanced retrograde transport properties in the ro...

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Literature Corpus work: cd912f6d-51e3-5e2d-90ed-fab6f0061af4
DOI: 10.1101/2025.07.07.663544

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Administration of barcoded AAV capsid library to the putamen of non-human primates identifies variants with efficient retrograde transportDOI 10.1101/2025.07.07.663544Read

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