Article

Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates

2023-01-13

Abstract excerpt

<h4>ABSTRACT</h4> Delivering genes to and across the brain vasculature efficiently and specifically across species remains a critical challenge for addressing neurological diseases. We have evolved adeno-associated virus (AAV9) capsids into vectors that transduce brain endothelial cells specifically and efficiently following systemic administration in wild-type mice with diverse genetic backgrounds and rats. Thes...

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Literature Corpus work: 4ea0c184-fdfa-594f-b388-d274c4c398a4
DOI: 10.1101/2023.01.12.523844

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