Article

Intravenous functional gene transfer throughout the brain of non-human primates using AAV

2023-01-13

Abstract excerpt

<title>Abstract</title> <p>Adeno-associated viruses (AAVs) promise robust gene delivery to the brain through non-invasive, intravenous delivery. However, unlike in rodents, few neurotropic AAVs efficiently cross the blood-brain barrier in non-human primates (NHPs). Here we describe AAV.CAP-Mac, an engineered variant identified by screening in adult marmosets and newborn macaques with improved efficiency in the br...

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Literature Corpus work: 38cbeeb4-30cd-5e00-8630-f14cf075b834
DOI: 10.21203/rs.3.rs-1370972/v1

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