Article

Single-Mitochondrion Sequencing Uncovers Distinct Mutational Patterns and Heteroplasmy Landscape in Mouse Astrocytes and Neurons

2024-06-13

Abstract excerpt

<h4>Background</h4> Mitochondrial (mt) heteroplasmy can cause adverse biological consequences when deleterious mtDNA mutations accumulate disrupting ‘normal’ mt-driven processes and cellular functions. To investigate the heteroplasmy of such mtDNA changes we developed a moderate throughput mt isolation procedure to quantify the mt single-nucleotide variant (SNV) landscape in individual mouse neurons and astrocyte...

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Literature Corpus work: c3a1dbc2-6f95-5116-971d-f99120c07871
DOI: 10.1101/2024.06.13.598906

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