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Article

Single-mitochondrion sequencing uncovers distinct mutational patterns and heteroplasmy landscape in mouse astrocytes and neurons.

BMC biology - 29 Jul 2024

Kadam Parnika S, Yang Zijian, Lu Youtao, Zhu Hua, Atiyas Yasemin, Shah Nishal, Fisher Stephen, Nordgren Erik, Kim Junhyong, Issadore David, Eberwine James

Abstract excerpt

BACKGROUND: Mitochondrial (mt) heteroplasmy can cause adverse biological consequences when deleterious mtDNA mutations accumulate disrupting "normal" mt-driven processes and cellular functions. To investigate the heteroplasmy of such mtDNA changes, we developed a moderate throughput mt isolation procedure to quantify the mt single-nucleotide variant (SNV) landscape in individual mouse neurons and astrocytes. In...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39075589
DOI: 10.1186/s12915-024-01953-7
PMCID: PMC11287894

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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