Article

Structural and biochemical characterization of the ALX4 dimer reveals novel insights into how disease alleles impact ALX4 function

2024-09-10

Abstract excerpt

1. How homeodomain proteins gain sufficient DNA binding specificity to regulate diverse processes has been a long-standing question. Here, we determine how the ALX4 Paired-like protein achieves DNA binding specificity for a TAAT – NNN – ATTA dimer site. We first show that ALX4 binds this motif independently of its co-factor, TWIST1, in cranial neural crest cells. Structural analysis identified seven ALX4 residues...

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Literature Corpus work: c39699c9-622b-530e-aea5-b831d7aa1b0a
DOI: 10.1101/2024.09.10.612331

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