Article
Structure of SALL4 zinc finger domain reveals link between AT-rich DNA binding and Okihiro syndrome.
Life science alliance - 1 Mar 2023
Watson James A, Pantier Raphaël, Jayachandran Uma, Chhatbar Kashyap, Alexander-Howden Beatrice, Kruusvee Valdeko, Prendecki Michal, Bird Adrian, Cook Atlanta G
Abstract excerpt
Spalt-like 4 (SALL4) maintains vertebrate embryonic stem cell identity and is required for the development of multiple organs, including limbs. Mutations in SALL4 are associated with Okihiro syndrome, and SALL4 is also a known target of thalidomide. SALL4 protein has a distinct preference for AT-rich sequences, recognised by a pair of zinc fingers at the C-terminus. However, unlike many characterised zinc finger...
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