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Aberrant homeodomain-DNA cooperative dimerization underlies distinct developmental defects in two dominant <i>CRX</i> retinopathy models

2024-03-14

Abstract excerpt

Paired-class homeodomain transcription factors (HD TFs) play essential roles in vertebrate development, and their mutations are linked to human diseases. One unique feature of paired-class HD is cooperative dimerization on specific palindrome DNA sequences. Yet, the functional significance of HD cooperative dimerization in animal development and its dysregulation in diseases remain elusive. Using the retinal TF Co...

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Identifiers and source

Literature Corpus work
6964d53c-f9a1-5129-8f45-0cdeb901ce84
DOI
10.1101/2024.03.12.584677
Open publication

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Aberrant homeodomain-DNA cooperative dimerization underlies distinct developmental defects in two dominant <i>CRX</i> retinopathy modelsDOI 10.1101/2024.03.12.584677
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