Article
The Wiskott-Aldrich syndrome: The actin cytoskeleton and immune cell function.
Disease markers - 1 Jan 2010
Blundell Michael P, Worth Austen, Bouma Gerben, Thrasher Adrian J
Abstract excerpt
Wiskott-Aldrich syndrome (WAS) is a rare X-linked recessive primary immunodeficiency characterised by immune dysregulation, microthrombocytopaenia, eczema and lymphoid malignancies. Mutations in the WAS gene can lead to distinct syndrome variations which largely, although not exclusively, depend upon the mutation. Premature termination and deletions abrogate Wiskott-Aldrich syndrome protein (WASp) expression and...
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